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50 YEAR OLD FEMALE WITH FEVER, LEFT LOIN PAIN

  This is an online E-log entry blog to discuss and understand the clinical data analysis of a patient, to develop competency in comprehending clinical problems, and providing evidence- based inputs in order to come up with a diagnosis and effective treatment plan to the best of my ability.


Mentioned here are my learning points, both theoretical and practical surrounding this patient:

-Taking psychosocial and past history of this patient was particularly eye opening. She had several hospital admissions in the last 2 years with 3 for pyelonephritis alone. Her history made me realize the hardships of patients with chronic health conditions, and the pain that both her and her family would have to suffer from it.

-I also got to learn the pathophysiology of PAH and how to causes murmurs. Additionally, I got to appreciate the murmurs in this patient as well.

-An interesting medical dilemma surrounding this patient was whether or not to give IV fluids. 2D ECHO showed a collapsing IVC along with cardiac failure. 


A 50 year old female came to the OPD with chief complaints of :

   -Fever since 1 week

   -Left loin pain since 1 week


HISTORY OF PRESENTING ILLNESS: 

Patient was apparently asymptomatic 12 years ago when she had an episode of giddiness. She went to the doctor for the same and was diagnosed with Type II DM. Since then, she has been on insulin ever since, and has been using it regularly.

In August 2021, she went to a physician again with complaints of fever and joint pains, wherein she was diagnosed with typhoid and treated for the same.

In October 2021, she had burning micturition and abdominal pain for 5 days, following which she went to the doctor. She was started on Tab. Nitrofurantoin.

In March 2022, she developed a fever, with nausea, decreased appetite and body pains since 10 days. She was diagnosed with Uncontrolled Type II DM with sepsis and pyelonephritis and admitted for the same until the pyelonephritis resolved.

In July 2022, she started having left loin pain along with abdominal pain, and a low grade fever with chills. She had also had 2 episodes of vomiting. She was admitted, and diagnosed with Diabetic Ketoacidosis with Recurrent Pyelonephritis.

In December 2022- she developed an ulcer over her left foot following an RTA (bike vs car), which later developed into an abscess. The abscess was drained, and the ulcer was left to heal.

In May 2023, she became drowsy and unresponsive, associated with sweating. Her GRBS was found to be 28mg/dl, and she was diagnosed with a hypoglycemic episode.

Since 3 months, the patient has had neck pain, radiating to both her upper limbs, and back. The pain is persistent, with no aggravating or relieving factors as such. Due to the pain, she has restriction of neck movements. 

1 week ago, she developed fever which was high grade, intermittent type and associated with chills and rigors. It was relieved on taking medication (Tab DOLO). There was no diurnal variation.

She also had left loin pain since 1 week, which was intermittent and dragging type, radiating towards the back, and was also relieved on taking medication.

Additionally, she had two episodes of vomiting 1 week ago, which was non projectile and non bilious, and contained food particles. 

No history of burning micturition, decreased urinary output, facial puffiness

No history of cough, cold, rash, loose stools


Due to these complaints, she came to the OPD and was advised admission based on her symptoms and previous history. She was not willing to be admitted that day due to her daughters being busy, and was admitted 5 days later.



PAST HISTORY

As mentioned, she has had similar complaints in the past.

She had a hysterectomy with bilateral salpingo-oophorectomy 14 years ago 

No history of HTN, CVD, CAD, thyroid, TB, asthma, epilepsy


PERSONAL HISTORY: 

Diet - vegetarian

Sleep - Disturbed since 3-4 months

Appetite - Decreased since 3-4 months

Bowel and bladder - regular

No addictions

No allergies  


PSYCHOSOCIAL HISTORY:

Patient is 50 years old 

She studied till 7th grade, after which she started involving herself in household work. She got married at 15 years, after which she was a housewife, and took care of all the household chores.

Before her diabetes diagnosis, she used to eat most foods. However, since her diagnosis, she has mostly been eating bajra and limited her consumption of rice. 

Since having diabetes, she used to wake up at 5am, finish her chores and have 1-2 rotis at 9am. She would have lunch at 1pm, which was usually bajra mixed with water. Then she would continue her household chores and have dinner at 9pm, which was also usually bajra. She would sleep by 10pm.

She is a vegetarian and hence does not consume meat.

Since 6 months, she has not been able to do any of her chores at home. She has mostly been restricted to her bed, and gets tired when she works for even short periods of time. Additionally due to her neck pain she has been having difficulty in doing normal activities also.


She feels that her disease has been a burden on her due to the constant hospital visits and the amount of money spent, ie, around 5 lakhs on treatment alone.


FAMILY HISTORY: 

No significant history  


GENERAL EXAMINATION: 

Patient is conscious, coherent and co-operative.

She is moderately built and moderately nourished.

Pallor - Present

Icterus - Absent

Cyanosis - Absent 

Clubbing - Absent 

No lymphadenopathy

Pedal edema- Absent

                                               

                                                                               Pallor noted



                                                   
                                                         Hyperpigmentation due to ?insulin
                     



                                                      Muscle wasting seen over biceps



Chronic healing ulcer over foot



                                                                            To note visceral fat


Vitals : 

Temperature - 96.8 ° F

Blood Pressure -130/70 mmHg

Pulse Rate -78 bpm

Respiratory Rate - 13 cpm

RBS - 158 gm/dl


SYSTEMIC EXAMINATION: 


PER ABDOMINAL EXAMINATION:

INSPECTION-

Shape of abdomen : flat

Umbilicus : inverted 

All quadrants of abdomen move with respiration 

No visible peristalsis, pulsations, sinuses, engorged veins, hernial sites 


PALPATION-

Abdomen soft

No local rise of temperature 

Tenderness present over left lumbar region

Inspectors findings are confirmed 

No palpable masses

Liver is not palpable 

Spleen is not palpable 


PERCUSSION:

Resonance note heard over all quadrants


AUSCULTATION:

Bowel sounds heard  


 

CVS EXAMINATION:

INSPECTION

The chest wall is bilaterally symmetrical

JVP raised in supine position, not raised on sitting/ standing

No dilated veins, scars or sinuses are seen

Apical impulse not visible


     Video showing raised JVP in supine position


PALPATION:

Apex beat diffuse


AUSCULTATION:

S1 and S2 heard

Murmurs heard over tricuspid and pulmonic region


RS EXAMINATION:

INSPECTION

Shape of chest: bilaterally symmetrical

Expansion of chest: Equal on both sides

Position of trachea: Central

No visible scars, sinuses, pulsations


PALPATION:

Inspectory findings confirmed

No tenderness, local rise of temperature

Normal expansion of chest on both sides in all areas

Position of trachea: Central

Vocal fremitus: resonant note felt


PERCUSSION:

Resonant note heard over all areas


AUSCULTATION:

BAE positive

Vocal resonance: resonant in all areas


CNS EXAMINATION:

HIGHER MENTAL FUNCTIONS

Normal

Memory intact


CRANIAL NERVES-

Normal


SENSORY EXAMINATION

Normal sensations felt in all dermatomes


MOTOR EXAMINATION

Normal tone in upper and lower limb

Normal power in upper and lower limb

Normal gait


REFLEXES

Normal, brisk reflexes elicited- biceps, triceps, knee and ankle reflexes elicited


PROVISIONAL DIAGNOSIS: 

HEART FAILURE SECONDARY TO HIGH OUTPUT FAILURE SECONDARY TO ANEMIA SECONDARY TO SEVERE PAH TYPE 2

DIABETIC NEPHROPATHY AND RETINOPATHY

IRON DEFICIENCY ANEMIA SECONDARY TO ?NUTRITIONAL ?ANEMIA OF CHRONIC DISEASE

DE NOVO HYPERTENSION

B/L ACUTE PYELONEPHRITIS

LEFT FOOT DIABETIC ULCER (RESOLVING)

ACUTE KIDNEY INJURY ON CKD (STAGE 4)



EVALUATION: 

Investigations done on 20/6/23:

Hemogram:

Hb: 6.7gm%

TLC: 9700

PCV: 20.4

MCV: 76.7

MCHC: 32.8

RBCs: 2.66lakhs/cumm

PLT: 1.96


LFT

TB: 0.62

DB: 0.20

AST: 15

ALT: 12

ALP: 377

TP: 5.5

Albumin: 3.0


RFT

Urea- 117

Creatinine- 5.7

Na: 130

K: 4.3

Cl: 98


CUE

Albumin +

Pus cells: 3-4

RBCs: NIL


FBS: 197 mg/dl

PLBS: 348 mg/dl

HBA1C: 6.5


Serum Osmolarity: 300.7

Urinary electrolytes:

Na: 142

K: 8.3

Cl: 115


24 hours urinary creatinine: 0.8g/day

24 hour urinary protein 720mg/day


22/6/23:

RFT

Urea: 108

Creatinine: 2.5

Na: 136

K: 4.1

Cl: 103


23/6/23:

RFT

Urea: 107

Creatinine: 4.5

Na: 132

K: 3.9

Cl: 98


24/6/23:

RFT

Urea: 100

Creatinine: 4.2

Na: 136

K: 4

Cl: 98


Updated fever chart:




USG abdomen:



Xray KUB:


ECG:


2DECHO:



2DECHO Report:


Xray SPINE:


ABG: 



CXR- PA:





SOAP NOTES:

 
23/6/23 
S: 
No fever spikes 
Passed stools yesterday 
Vomiting 2 episodes after food

O: 
Pt is c/c/c
Pallor present
BP - 110/70 mmHg
PR- 92 bpm 
RR - 22 cpm 
Temp - Afebrile
GRBS -168mg/dl 
SpO2 - 98% @RA
CVS - S1 S2 heard , no murmurs 
RS - BAE+ no added sounds 
P/A - soft and non tender, mild spleenomegaly 
CNS - no FND

A: 
HEART FAILURE SECONDARY TO HIGH OUTPUT FAILURE SECONDARY TO ANEMIA
SEVERE PAH TYPE 2
DIABETIC NEPHROPATHY AND RETINOPATHY
IRON DEFICIENCY ANEMIA SECONDARY TO ?NUTRITIONAL ?ANEMIA OF CHRONIC DISEASE
DE NOVO HYPERTENSION
B/L ACUTE PYELONEPHRITIS (RESOLVED)
LEFT FOOT DIABETIC ULCER (RESOLVING)
ACUTE KIDNEY INJURY ON CKD(STAGE 4) ?RENAL ?PRE RENAL
                                             

P:
SALT RESTRICTION 
IV FLUIDS NS @UO + 30ML/HR
INJ.PAN 40 MG IV/OD 8 AM
INJ.IRON SUCROSE 100MG IV/ALTERNATE DAY (NEXT DOSE-24/6/23)
INJ.ERYTHROPOETIN 4000IU SC/ONCE WEEKLY (NEXT DOSE-29/06/23)
INJ.ZOFER 4MG IV/SOS
INJ.LASIX 20MG/IV/OD-2PM
TAB.CINOD 10MG/PO/OD
TAB. ULTRACET PO/QID HALF TABLET
TAB.NODOSIS 500MG/PO/BD
CAPSULE CUDCE FORTE PO/OD
POWDER FIDOTOX IN 1 GLASS OF WATER


24/6/2023
S: 
Stools passed yesterday
4-5 episodes of vomiting during the daytime
Neck pain +, nausea +
Generalized weakness+, appetite- normal

O: 
Pt is c/c/c
Pallor present
BP - 140/80 mmHg
PR- 99bpm 
RR - 25 cpm 
Temp - Afebrile
GRBS -207mg/dl 
SpO2 - 98% @RA
CVS - S1 S2 heard , no murmurs 
RS - BAE+ no added sounds 
P/A - soft and non tender
CNS - no FND

A:
HEART FAILURE SECONDARY TO HIGH OUTPUT FAILURE SECONDARY TO ANEMIA SECONDARY TO SEVERE PAH TYPE 2
DIABETIC NEPHROPATHY AND RETINOPATHY
IRON DEFICIENCY ANEMIA SECONDARY TO ?NUTRITIONAL ?ANEMIA OF CHRONIC DISEASE
DE NOVO HYPERTENSION
B/L ACUTE PYELONEPHRITIS (RESOLVED)
LEFT FOOT DIABETIC ULCER (RESOLVING)
ACUTE KIDNEY INJURY ON CKD(STAGE 4)
                                             

P:
SALT RESTRICTION 
IV FLUIDS NS @UO + 30ML/HR
INJ.PAN 40 MG IV/OD 8 AM
INJ.IRON SUCROSE 100MG IV/ALTERNATE DAY (NEXT DOSE-24/6/23)
INJ.ERYTHROPOETIN 4000IU SC/ONCE WEEKLY (NEXT DOSE-29/06/23)
INJ.ZOFER 4MG IV/SOS
INJ.LASIX 20MG/IV/OD-2PM
TAB.CINOD 10MG/PO/BD
TAB. ULTRACET PO/QID HALF TABLET
TAB.NODOSIS 500MG/PO/BD
CAPSULE CUDCE FORTE PO/OD
POWDER FIDOTOX IN 1 GLASS OF WATER
PHYSIOTHERAPY FOR NECK PAIN


25/6/23:
S:
1 episode of vomiting (nausea+)
left Ear pain and discharge since yesterday 
Neck pain +

O: 
Pt is c/c/c
Pallor present
BP - 140/80 mmHg
PR- 82bpm 
RR - 25cpm 
Temp - Afebrile
GRBS -206mg/dl 
SpO2 - 99% @RA
CVS - S1 S2 heard , no murmurs 
RS - BAE+ no added sounds 
P/A - soft and non tender, mild hepatomegaly 
CNS - no FND
Neck- diffuse tenderness over nape of neck
ROM -mild limitations over all ranges
Ear discharge present 

A: 
1.Severe PAH type 2, Secondary High Output Heart Failure Seconday to Severe Anemia 
2 Iron deficiency anemia secondary to?Nutritional
?Anemia of chronic disease 
3 Diabetic nephropathy and retinopathy 
4 Denovo hypertension 
5 Acute kidney injury on chronic kidney disease 
6 Left foot diabetic ulcer (resolving)
7 B/l acute pyelonephritis (resolved)
8 Left Csom mucosal type active stage with left mild conductive hearing loss
9 Renal osteodystrophy with myalgia 

P:                                                               
IV FLUIDS NS @UO + 30ML/HR
INJ.PAN 40 MG IV/OD 8 AM
INJ.IRON SUCROSE 100MG IV/ALTERNATE DAY (NEXT DOSE-26/6/23)
INJ.ERYTHROPOETIN 4000IU SC/ONCE WEEKLY (NEXT DOSE-29/06/23)
INJ.ZOFER 4MG IV/SOS
INJ.LASIX 20MG/IV/OD-2PM
TAB.CINOD 10MG/PO/BD
TAB.NODOSIS 500MG/PO/BD
CAPSULE CUDCE FORTE PO/OD
POWDER FIDOTOX IN 1 GLASS OF WATER
Ciplox ear drops 3/3/3
Keep ears dry 
Cystaflam gel for L/A for neck 
Hot water fermentation for neck 
Active neck movements 
PHYSIOTHERAPY FOR NECK PAIN


26/6/2023

S: 
Ear pain- decreased 
Ear discharge absent 
Neck pain + and general weakness since 6 months 

O: 
Pt is c/c/c
Pallor present
BP - 140/80 mmHg
PR- 86bpm 
RR - 24hrs 
Temp - 100.3 F 
GRBS -198 mg/dl 
SpO2 - 99% @RA
CVS - S1 S2 heard , apex diffuse
RS - BAE+ no added sounds 
P/A - soft and non tender, mild hepatomegaly 
CNS - no FND
Neck- diffuse tenderness over nape of neck
ROM -mild limitations over all range

A: 
1.Severe PAH type 2, Secondary High Output Heart Failure Seconday to Severe Anemia 
2 Iron deficiency anemia secondary to?Nutritional
?Anemia of chronic disease 
3 Diabetic nephropathy and retinopathy 
4 Denovo hypertension 
5 Acute kidney injury on chronic kidney disease 
6 Left foot diabetic ulcer (resolved)
7 B/l acute pyelonephritis (resolved)
8 Left Csom mucosal type active stage with left mild conductive hearing loss
9 Renal osteodystrophy of neck with myalgia 

                                                                P:
1. Salt restriction < 2 g/day 
2. IV FLUIDS 0.9NS UO+ 30ml/hr
3. INJ LASIX 20mg/IV/OD
4. INJ ERYTHROPOIETIN 4000 IU/SC once weekly (next dose- 29/6/23) 
5. INJ PAN 40 mg IV/OD
6. INJ ZOFER 4 mg IV/SOS
7. TAB CINOD 10 mg PO/BD 
8. TAB CARVEDILLO 3.125 mg PO/BD 
9. TAB NODOSIS 1gm PO/BD 
10. CAP CUDCE FORTE PO/OD 
11. TAB PCM 650mg PO/SOS 
12. TAB CIPLOX EAR DROPS
13. Keep ears dry
14. CEBHYDRA LOTION OR LIQ PARAFFIN L/A/BD 
15. TAB OROFER- XT PO/OD 
16. CYSTAFLAM GEL FOR L/A
17. Hot water fomentation
18. Active neck movements


ADVICE AT DISCHARGE:

SALT RESTRICTION <2G/DAY
TAB LASIX 20MG PO OD AT 2PM FOR 20 DAYS
HAI 7AM--1PM--7PM
           8U      8U     8U
NPH 7AM--1PM--7PM
          6U        X        6U
INJ EPO 4000 IU SC ONCE WEEKLY - ONLY FOR 1 WEEK
TAB PAN 40MG PO OD AT 7AM FOR 1 WEEK
TAB NICARDIA 10MG PO QID TO BE CONTINUED
TAB CARVEDILOL 3.125MG PO OD TO BE CONTINUED
TAB NODOSIS 1GM PO BD TO BE CONTINUED
CAPSULE CUDSE FORTE PO OD 8AM FOR 1 WEEK
PLANT BASED PROTEIN POWDER 2 SCOOPS PO TID FOR ONE WEEK
OROFER XD PO OD AT 2PM FOR 1 MONTH
PHYSIOTHERAPY FOR NECK PAIN
CYSTATLAM GEL LA TWICE A DAY FOR ONE WEEK
HOT WATER FOMENTATION
ACTIVE NECK MOVEMENTS
PLENTY OF ORAL FLUIDS

REVIEW AFTER 2 WEEKS WITH HEMOGRAM REPORTS


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